A possible Super Bowl preview and intra-divisional matchups highlight the schedule for Week 10 of the 2012 NFL season. Here's a preview of this week's games:

Thursday, Nov. 8

Indianapolis Colts at Jacksonville Jaguars — 8:20 P.M.

EverBank Field, Jacksonville, Fla.
The Jaguars' defense must control the Colts' tandem of quarterback Andrew Luck and wide receiver Reggie Wayne, which has helped give Indianapolis (5-3) the league's fourth-ranked total offense, averaging 390.9 yards per game. Jacksonville (1-7) will again be without running back Maurice Jones-Drew, who is still recovering from a foot injury. He ran for 177 yards in the Jaguars' 22-17 win over the Colts in Week 3. Jacksonville is last in the NFL in total offense, averaging 254.4 yards per game.

Sunday, Nov. 11

N.Y. Giants at Cincinnati Bengals — 1:00 P.M.

Paul Brown Stadium, Cincinnati
Quarterback Eli Manning has thrown for 2,426 yards for New York (6-3). He'll likely lead the way against a Bengals' defense that has allowed 27.3 points per game. Cincinnati (3-5) is on the verge of falling out of playoff contention. Quarterback Andy Dalton will look for opportunities against a vulnerable Giants' pass defense that ranks 26th in the NFL.

Tennessee Titans at Miami Dolphins — 1:00 P.M.

Sun Life Stadium, Miami
Tennessee (3-6) could see the return of quarterback Jake Locker from injury this week. The Titans' offense ranks 30th in time of possession, thanks in part to an inconsistent running game. The Dolphins' defense ranks third in the NFL against the run. Miami (4-4) hopes its offense can perform well against a Titans' defense that gives up a league-high 34.2 points per game and allows an average of 414.2 yards per game.

Detroit Lions at Minnesota Vikings — 1:00 P.M.

Mall of America Field, Minneapolis
Behind quarterback Matthew Stafford, Detroit (4-4) has the NFC's top-ranked total offense, averaging 410.9 yards per game. The Vikings' defense has 24 sacks and ranks ninth in the league against the pass. Saddled with the NFL's 30th-ranked pass offense, Minnesota (5-4) centers its offensive attack around Adrian Peterson, the NFL's leading rusher with 957 yards. The Lions have the league's seventh-ranked total defense. Detroit must tighten up its special teams, which let them down in a 20-13 loss to the Vikings in Week 4.

Buffalo Bills at New England Patriots — 1:00 P.M.

Gillette Stadium, Foxborough, Mass.
Buffalo (3-5) relies on a rushing attack that ranks sixth in the league at 141.3 yards per game. The Patriots' defense is more susceptible to the pass, but they have nine interceptions and an AFC-high 14 forced fumbles. Quarterback Tom Brady directs the offense for New England (5-3), which dominated the Bills, 52-28, Week 4. Brady faces a Buffalo defense that gives up 31 points per game and ranks 31st overall in total yards allowed per game.

Atlanta Falcons at New Orleans Saints — 1:00 P.M.

Mercedes-Benz Superdome, New Orleans
Quarterback Matt Ryan leads Atlanta (8-0) and its potent offense against a Saints' defense that yields a league-high 471.3 yards per game. New Orleans (3-5) has the NFL's fifth-ranked total offense thanks to quarterback Drew Brees. Though it gives up significant yardage, the Falcons' defense allows just 17.9 points per game, the league's fifth-lowest per game average.

San Diego Chargers at Tampa Bay Buccaneers — 1:00 P.M.

Raymond James Stadium, Tampa, Fla.
San Diego (4-4) needs Philip Rivers to lead the Chargers' offense against a Buccaneers' defense that is the best in the league against the run, but worst against the pass. Tampa Bay (4-4) may have found a franchise running back in Doug Martin, who has rolled up 386 yards and six touchdowns in the past two weeks. Martin will test a Chargers' defense that ranks fourth against the run, allowing just 84 yards per game.

Denver Broncos at Carolina Panthers — 1:00 P.M.

Bank of America Stadium, Charlotte
Largely due to the play of Peyton Manning, the league's top-rated quarterback, Denver (5-3) has the third-ranked total offense in the league. Manning will need to overcome a Panthers' defense that harassed Robert Griffin III in a victory over the Redskins last week. Carolina (2-6) scores just 18.6 points per game. Quarterback Cam Newton must be aware of an aggressive Broncos' pass rush whose 24 sacks tie them for the AFC lead with the Texans.

Oakland Raiders at Baltimore Ravens — 1:00 P.M.

M&T Bank Stadium, Baltimore
Oakland (3-5) has the worst rushing offense in the AFC, averaging just 77.3 yards per game. As a result, the Raiders have leaned on Carson Palmer and the NFL's seventh-ranked pass offense. The Ravens are second in the AFC in interceptions, but are uncharacteristically weak against the run, ranking 28th in the league. Baltimore (6-2) may use running back Ray Rice often against a Raiders' defense that was gashed for 251yards by the Buccaneers' Doug Martin in last week's loss. Oakland allows 28.6 points per game, the fourth-worst average in the league.

N.Y. Jets at Seattle Seahawks — 4:05 P.M.

CenturyLink Field, Seattle
New York (3-5) has a woeful offense that ranks 27th in the league with a 317.4 yards per game average. Quarterback Mark Sanchez will face the Seahawks' fourth-ranked overall defense, which allows just 17.1 points per game. Seattle (5-4) figures to use running back Marshawn Lynch against a Jets' defense that allows 141.4 rushing yards per game, ranking it 29th in the NFL.

St. Louis Rams at San Francisco 49ers – 4:25 P.M.

Candlestick Park, San Francisco
Averaging just 17.1 points per game, St. Louis (3-5) has not been effective on offense. The Rams may not have many scoring opportunities against a 49ers' team that ranks No.1 in the NFC in total defense and holds opponents to a league-low 12.9 points per game. San Francisco (6-2) has the league's best rushing attack at 168.6 yards per game, and quarterback Alex Smith is completing nearly 70 percent of his pass attempts. The Rams' defense hopes to pressure Smith and add to its 21 sacks.

Dallas Cowboys at Philadelphia Eagles — 4:25 P.M.

Lincoln Financial Field, Philadelphia
Philadelphia (3-5) rolled up nearly 500 total yards in Monday night's loss to the Saints, but the Eagles may not do the same against a Cowboys' defense that ranks fifth-overall in the league. After allowing Michael Vick to be sacked seven times on Monday, the Eagles must address their offensive line problems. Dallas (3-5) has been effective on offense in most games, but quarterback Tony Romo has thrown a league-high 13 interceptions. He should have time to throw, as Philadelphia has a league-low 11 sacks.

Houston Texans at Chicago Bears — 8:20 P.M.

Soldier Field, Chicago
Houston (7-1) travels to Soldier Field in a potential Super Bowl preview. The Texans' offense scores 29.6 points per game behind Arian Foster and the league's eighth-ranked rushing offense. Led by Brian Urlacher, the Bears' defense has been lethal, allowing just 15 points per game, picking off a league-high 17 passes and registering 25 sacks. Quarterback Jay Cutler leads Chicago (7-1) against a Texans' defense that ranks third-overall in the NFL and defends both the pass and the run well.

Monday, Nov. 12

Kansas City Chiefs at Pittsburgh Steelers — 8:30 P.M.

Heinz Field, Pittsburgh
Kansas City (1-7) averages just 16.6 points per game, tied for 29th best in the NFL. If Brady Quinn has recovered from a head injury, he could replace turnover-plagued Matt Cassel at quarterback, but it may not matter against a Steelers' defense that ranks No. 1 in the league against the pass. Pittsburgh (5-3) is most effective when its running game balances out Ben Roethlisberger's down field strikes.

Bye Week:
Cleveland Browns, Green Bay Packers, Arizona Cardinals, Washington Redskins